In December of 2002 I was in Rome on business, so I took one day to see the Vatican. Great timing as it was chilly (not hot and humid as in summer) and it actually was very empty (strange for me just before Christmas). Sophie was also there so she joined me. We tried to see as much as we could of the Vatican and Rome. Rome also has some great shopping by the Spanish Steps. So men beware, your female counterpart might exercise the credit card liberally when visiting :-).
All in all it was a great experience and definitely the best European city I have visited so far.
Enjoy the Rome pictures. Unfortunately I only had a throw away camera so the quality is not always the best.
For more info on Rome you can go to http://www.twenj.com/romesightsretreat.htm